Apocynum venetum Extract Does Not Induce CYP3A and P-Glycoprotein in Rats

DOI Web Site Web Site PubMed 被引用文献1件 参考文献25件
  • Kobayashi Michiya
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Saitoh Hiroshi
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido
  • Seo Shujiro
    Tokiwa Phytochemical Co.
  • Butterweck Veronika
    College of Pharmacy, Department of Pharmaceutics, University of Florida
  • Nishibe Sansei
    Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido

この論文をさがす

抄録

We investigated the effect of Apocynum venetum L. extract (AV) on the activity of cytochrome P450 (CYP) 3A and P-glycoprotein (P-gp). The plasma concentration of nifedipine (NF), which is a substrate for CYP3A, did not change after oral administration with AV (3.3 mg/kg). Also, AV (3.3 and 33 mg/kg) did not affect the intestinal absorption of NF. In the rats treated with multiple administrations (15 mg/kg/d) of St. John's wort extract (SJW) for 2 weeks, the plasma concentration of NF after oral administration was significantly decreased. On the other hand, there was no significant differences in the pharmacokinetic parameters of NF between AV-treated (3.3 mg/kg/d) and none-treated rats. Furthermore, the intestinal absorption of methylprednisolone, which is a substrate for P-gp, was not affected by AV treatment for 2 weeks. These results suggest that, unlike SJW, the recommended dose of AV (3.3 mg/kg/d) would not influence hepatic CYP3A and intestinal P-gp in rats.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (25)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ