Reduction of the Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone

• Ishida Takumi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Oshimo Tomomi

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Nishimura Akihisa

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Mutoh Junpei

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Ishii Yuji

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Koga Nobuyuki

  Department of Food and Nutrition, Nakamura Gakuen University

• Yamada Hideyuki

  Graduate School of Pharmaceutical Sciences, Kyushu University

• Hashiguchi Isao

  Graduate School of Dental Sciences, Kyushu University

• Akamine Akifumi

  Graduate School of Dental Sciences, Kyushu University

• Oguri Kazuta

  Faculty of Pharmaceutical Sciences, Kyushu University of Health and Welfare

抄録

The protective effect of geranylgeranylacetone (GGA), an antiulcer drug, against the acute toxicity and teratogenicity produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in C57BL/6J mice. When mice were co-treated, GGA reduced the loss of body weight gain and lethality produced by TCDD but hepatomegaly and thymic atrophy were not improved. Additionally, no protective effect of GGA was observed in the formation of cleft palate and hydronephrosis in mouse fetuses caused by maternal exposure to TCDD. To clarify the reducing mechanism by GGA, the Hsp70.1 mRNA levels in liver and intestine were analyzed. However, it was difficult to explain the effect of GGA from the induction of Hsp70.1. GGA had also no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that GGA exhibits a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of arylhydrocarbon receptor activation.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 27 (9), 1397-1402, 2004

  公益社団法人 日本薬学会

キーワード

• 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD)
• geranylgeranylacetone (GGA)
• reduction
• toxicity
• wasting syndrome

詳細情報

• CRID: 1390282679602762880
• NII論文ID: 110003608983
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.27.1397
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7056638
• PubMed: 15340226
• Web Site: http://id.ndl.go.jp/bib/7056638
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7056638
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/9/27_9_1397/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006100027
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可