HIV-1 Inhibitory Compounds from Calophyllum brasiliense Leaves

• Huerta-Reyes Maira

  Department of Natural Products, Institute of Chemistry, National University of Mexico

• Basualdo Maria del Carmen

  HIV/AIDS Section, Institute of Biomedical Sciences, National University of Mexico

• Abe Fumiko

  Faculty of Pharmaceutical Sciences, Fukuoka University

• Jimenez-Estrada Manuel

  Department of Natural Products, Institute of Chemistry, National University of Mexico

• Soler Carmen

  HIV/AIDS Section, Institute of Biomedical Sciences, National University of Mexico

• Reyes-Chilpa Ricardo

  Department of Natural Products, Institute of Chemistry, National University of Mexico

抄録

The hexane, acetone and methanol extracts of Calophyllum brasiliense leaves were fractionated following a three bioassay guide: high HIV-1 RT inhibition, low cytotoxicity on MT2 cells and high inhibition of HIV-1 IIIb/LAV replication. This led to the isolation of three anti HIV-1 dipyranocoumarins: calanolides A and B and soulattrolide. In contrast, other isolated compounds such as apetalic acid, isoapetalic acid, a structural isomer of isoapetalic acid, friedelin, canophyllol and amentoflavone were devoid of HIV-1 RT inhibitory activity. Calanolide C was also obtained as a natural product and showed moderate inhibitory properties.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 27 (9), 1471-1475, 2004

  公益社団法人 日本薬学会

キーワード

• <i>Calophyllum brasiliense</i>
• HIV-1 RT
• calanolide

詳細情報

• CRID: 1390001204626088064
• NII論文ID: 110003609000
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.27.1471
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 7056723
• PubMed: 15340243
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7056723
• Web Site: http://www.jstage.jst.go.jp/article/bpb/27/9/27_9_1471/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2006100044
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可