マウスにおけるニッケルアレルギーの評価

• 丸山 登久子

  <i>武庫川女子大学薬学部</i>

• 片岡 裕美

  <i>武庫川女子大学薬学部</i>

• 扇間 昌規

  <i>武庫川女子大学薬学部</i>

• 伊藤 誉志男

  <i>武庫川女子大学薬学部</i>

書誌事項

タイトル別名

• Evaluation of Nickel Allergy in Mice
• マウス ニ オケル ニッケルアレルギー ノ ヒョウカ

抄録

This study was performed to establish a convenient mouse model for the evaluation of nickel allergy. For sensitization, 0.2g of nickel sulfate in petrolatum was applied 4 times every other day to the shaved dorsal skin. Seven days after the first application of the nickel sulfate salt sample, the antigen-specific metal allergy reaction was estimated based on the swelling response of the footpad injected with 20 μl of nickel sulfate salt in saline. Percutaneously applied nickel powder in petrolatum, as well as the original nickel salt sample, induced a significant nickel allergy reaction. Therefore, it is suggested that this system is applicable for the evaluation of antimetal allergic substances.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 123 (8), 707-715, 2003-08-01

  公益社団法人 日本薬学会

キーワード

• nickel allergy
• mouse model
• footpad
• metal allergy

詳細情報

• CRID: 1390282681104505344
• NII論文ID: 110003614920
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.123.707
• COI: 1:STN:280:DC%2BD3szpsFWntQ%3D%3D
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 6658531
• PubMed: 12931667
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6658531
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/123/8/123_8_707/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003314543
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可