Eurycomaoside: A New Quassinoid-Type Glycoside from the Roots of Eurycoma longifolia

  • Bedir Erdal
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi
  • Abou-Gazar Hassan
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi
  • Ngwendson Julius Ngunde
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi Department of Chemistry, University of Buea
  • Khan Ikhlas Ahmad
    National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi Department of Pharmacognosy, School of Pharmacy, University of Mississippi

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A new C19-quassinoid-type glycoside has been isolated from the roots of Eurycoma longifolia. The structure elucidation of the compound was achieved by a combination of one- and two-dimensional NMR techniques, including 1H–1H-correlation spectroscopy (COSY), 1H–13C-heteronuclear correlation spectroscopy (HMQC), and 1H–13C-heteronuclear multiple-bond correlation spectroscopy (HMBC), as well as high resolution electrospray ionization Fourier transformation mass spectrometry (HR-ESI-FT-MS) data. The C(1)-glycosidation site in the quassinoid framework is encountered for the first time.

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