Diastereoselective Solid-Phase Radical Addition to Oxime Ether Anchored to Polymer Support

• Miyabe Hideto

  Kobe Pharmaceutical University

• Konishi Chihiro

  Kobe Pharmaceutical University

• Naito Takeaki

  Kobe Pharmaceutical University

Abstract

Stereocontrol in radical reactions of oxime ether anchored to polymer support was studied. Highly diastereoselective solid-phase radical reaction was achieved by using triethylborane and diethylzinc as a radical initiator at low reaction temperature, providing a novel method for the synthesis of the α-amino acid derivatives with excellent diastereoselectivities.

Journal

• Chemical and Pharmaceutical Bulletin

  Chemical and Pharmaceutical Bulletin 51 (5), 540-544, 2003

  The Pharmaceutical Society of Japan

Keywords

• solid-phase
• radical reaction
• oxime ether
• diastereoselective

Details

• CRID: 1390282679139077504
• NII Article ID: 110003615345
• NII Book ID: AA00602100
• DOI: 10.1248/cpb.51.540
• COI: 1:CAS:528:DC%2BD3sXltVejs7Y%3D
• ISSN: 13475223
• ISSN: 00092363
• NDL BIB ID: 6517028
• PubMed: 12736453
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6517028
• Web Site: http://www.jstage.jst.go.jp/article/cpb/51/5/51_5_540/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed