A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. 9. Controlled-Release of Theophylline from Double-Compressed Tablet Composed of Cellulose Derivatives as Wall Material

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  • ITO Kousuke
    Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University
  • KONDO Shin-ichi
    Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University
  • KUZUYA Masayuki
    Laboratory of Pharmaceutical Physical Chemistry, Gifu Pharmaceutical University

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タイトル別名
  • A New Drug Delivery System Using Plasma-Irradiated Pharmaceutical Aids. IX. Controlled-Release of Theophylline from Double-Compressed Tablet Composed of Cellulose Derivatives as Wall Material.
  • New Drug Delivery System Using Plasma Irradiated Pharmaceutical Aids 9 Controlled Release of Theophylline from Double Compressed Tablet Composed of Cellulose Derivatives as Wall Material

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The rapid release from a double-compressed tablet containing theophylline with the water-soluble polymer, hydroxypropylmethylcellulose (HPMC) or hydroxypropylmethylcellulose phthalate (HPMCP), used as a wall material can be suppressed by argon plasma-irradiation and changed into the sustained-release system due to a decrease in solubility of the outer layer. It was shown that the release profiles can be varied so as to cause theophylline release at different rates, depending on the set of conditions chosen for tablet manufacture and for plasma operation.

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