Optimum Conditions for the 13C-Phenylalanine Breath Test.

• ISHII Toshihiro

• TAKATORI Kazuhiko

• IIDA Katsumi

• HIGUCHI Teruhiko

• OHSHIMA Akihiko

• NARUSE Hiroshi

• KAJIWARA Masahiro

書誌事項

タイトル別名

• Optimum Conditions for the 13C-Phenylal

抄録

We have conducted optimizaiton studies to develop a superior ¹³C-phenylalanine breath test for the diagnosis of liver disease. First, we examined the optimum ¹³C-labeling position in phenylalanine for use in a breath test based on infrared spectroscopic detection of ¹³CO₂ in exhaled air. L-[1-¹³C]Phenylalanine gave the best result. Next, a suitable dosage to give a short peak time (the time expressed in minutes as which ¹³CO₂ excretion is maximal) after administration was determined. The ¹³CO₂/¹²CO₂ ratio in exhaled air after administration of 100 mg/body of L-[1-¹³C]phenylalanine peaked sharply at 15 min. We also examined the effect of food on the hepatic metabolism of L-[1-¹³C]phenylalanine. We found that a fasting period of over 7 h before the test resulted in a higher ¹³CO₂ peak excretion. The peak appeared sooner than that in the ¹³C-phenacetin breath test and, therefore, the ¹³C-phenylalanine breath test appears preferable for the rapid evaluation of hepatic function.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 46 (8), 1330-1332, 1998

  公益社団法人 日本薬学会

キーワード

• ^<13>C-phenylalanine
• ^<13>C-phenacetin
• breath test
• liver disease
• diagnosis

詳細情報

• CRID: 1390001204161811328
• NII論文ID: 110003617031
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.46.1330
• COI: 1:CAS:528:DyaK1cXlsFyju7o%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• NDL書誌ID: 4540763
• PubMed: 9734317
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4540763
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/46/8/46_8_1330/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999001557
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可