Studies on Nucleic Acid Antagonists. II. Structure-Activity Relationship in 5-Phenylazopyrimidines.
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- 田中 邦喜
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 大村 栄之助
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 川島 実
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 渡辺 順明
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 横谷 肇
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 伊藤 宝務
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 杉野 幸夫
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 石館 基
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 荒木 豊成
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 荒蒔 義知
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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- 梶原 彊
- Research Laboratories, Takeda Pharmaceutical Industries, Ltd.
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抄録
Among the 5-phenylazopyrimidine derivatives reported in the preceding paper, some members showed a remarkable inhibitory effect upon the growth of Lactobacillus casei, Tetrahymena geleii, as well as chick embyro fibroblast. Others which were only slightly effective, had anti-tumor activity against Yoshida sarcoma and Ehrlich carcinoma. As a result of study on the structure-activity relationships in these compounds, it was found that 2,4,6-triamino-5-phenylazopyrimidines, in which the para-position of the benzene ring of the 5-phenylazogroup was substituted with sulfonic acid, sulfonamide, carboxylic acid, or phosphonic acid group, were effective upon several transplantable tumors in experimental animals and their anti-tumor activity increased by a combined administration with other nucleic acid antagonists such as 6-mercaptopurine.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 7 (1), 7-12, 1959-02-10
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1573105977282838784
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- NII論文ID
- 110003618099
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles