Steroid Series. IX.A New Route to 6-Nitrosteroid Derivatives

• 田辺 克巳

  Takamine Laboratory, Sankyo Co., Ltd.

• 林 了三

  Takamine Laboratory, Sankyo Co., Ltd.

抄録

Treatment of cholesterol acetate (Ia), androst-5-ene-3β, 17β-diol diacetate (Ib), and 3β-hydroxyalndrost-5-en-17-one acetate (Ic) with nitrosyl chloride afforded the corresponding 5α-chloro-6β-nitro compound in high yield. The adduct could be converted readily to a Δ⁵-6-nitro compound on treatment under basic conditions and also into a Δ⁴-3-oxo-6α-nitrosteroid derivative.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 10 (12), 1177-1183, 1962

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679146969728
• NII論文ID: 110003618790
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.10.1177
• COI: 1:CAS:528:DyaF3sXkt1Wqt7s%3D
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 13990338
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/10/12/10_12_1177/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1963023513
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可