Alternative synthesis of substance P.

• 北川 幸己

• 伴 裕子

• 秋田 正

• 瀬川 富朗

• 仲田 義啓

• 矢島 治明

抄録

A bovine hypothalamic peptide, substance P was synthesized alternatively by successive condensation of three subunits, N-terminal di-, middle hepta- and C-terminal dipeptides. Two newly synthesized peptides, PCA-Phe-Phe-Gly-Leu-Met-NH₂ and PCA-Gln-Phe-Phe-Gly-Leu-Met-NH₂ were both found to be approximately two times active than synthetic substance P, when the contractile activity was determined in isolated guinea-pig ileum.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 26 (5), 1604-1607, 1978

  公益社団法人 日本薬学会

キーワード

• smooth muscle contractile activity

詳細情報

• CRID: 1390001204168519168
• NII論文ID: 110003623176
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.26.1604
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/26/5/26_5_1604/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1979071202
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可