Atropine-like activities of 2-substituted 5-piperidinomethylfuran derivatives.

• 太田 和子

• 高柳 一成

• 日比 悦子

• 高木 敬次郎

抄録

2-Substituted 5-piperidinomethylfuran derivatives were synthesized and their atropine-like and antihistamine activities were tested. The pA₂ values of the tested compounds for atropine-like activity were 7.50 to 5.21, less than that for atropine. The antihistamine activities (pA₂ values : 6.64 to 4.31) were much less than that of chlorpheniramine. Methylation of piperidine essentially did not affect the atropine-like activities but considerably decreased both the competitive and noncompetitive antihistamine activities.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 27 (12), 3149-3152, 1979

  公益社団法人 日本薬学会

キーワード

• effect of methylation of piperidine

詳細情報

• CRID: 1390282679142047616
• NII論文ID: 110003623588
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.27.3149
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 44228
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/27/12/27_12_3149/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1980109854
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可