DETECTION OF A NEW SERIES OF MONOAMINE OXIDASE INHIBITORS

• 甲斐 麻美子

  Faculty of Pharmaceutical Sciences, Kyushu University

• 野田 敦子

  Faculty of Pharmaceutical Sciences, Kyushu University

• 野田 浩司

  Department of Hospital Pharmacy, School of Medicine, University of Occupational and Environmental Health, Japan

• 後藤 茂

  Faculty of Pharmaceutical Sciences, Kyushu University

抄録

A new series of monoamine oxidase (MAO) inhibitors structurally analogous to tetrazolo [5,1-a] phthalazine (Tetra-P) was detected using rat brain mitochondrial MAO. In the tricyclic group, naphtetrazole (NTE) indicated a marked potency of MAO inhibition almost equal to that of iproniazid, and naphtriazole (NTR) showed similar potency as did Tetra-P. The nonselective and competitive inhibition for both types, MAO-A and MAO-B, was observed in some Tetra-P analogues.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 33 (12), 5585-5588, 1985-12-25

  公益社団法人日本薬学会

キーワード

• Tetra-P analogue
• MAO inhibitor
• rat brain mitochondrial MAO
• nonselective inhibition
• competitive inhibition
• fluorometry

詳細情報

• CRID: 1571135652461740544
• NII論文ID: 110003625387
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1988179853
• 本文言語コード: en
• データソース種別:
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