Antitumor Activity of Pt(II) Complexes Containing Diaminocarboxylates and Their Ester Derivatives
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- 野路 雅英
- Faculty of Pharmaceutical Sciences, Nagoya City University
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- 花村 真吾
- Faculty of Pharmaceutical Sciences, Nagoya City University
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- 鈴木 憲治郎
- Department of Pharmacy, Tokai Teishin Hospital
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- 田代 田鶴子
- Division of Experimental Chemotherapy, Cancer Chemotherapy Center
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- 喜谷 喜徳
- Faculty of Pharmaceutical Sciences, Nagoya City University
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Antitumor Pt(II) complexes containing ester derivatives of DL-2,3-diaminopropionate and DL-2,4-diaminobutyrate were synthesized and their structures were determined from their infrared and ultraviolet absorption spectral data. The antitumor activity of these Pt(II) complexes was tested in vivo against leukemia L1210 according to the NCI Pt Analog Protocol. [Pt(Malonato)(DL-2,3-diaminopropionate ethyl ester)] exhibited the highest antitumor effect with a T/C% value of 364 at an administration dose of 100 mg.The partition coefficients between water and n-octanol were measured, but no clear correlation with antitumor effects was found.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 34 (6), 2487-2493, 1986-06-25
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1573668927252709632
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- NII論文ID
- 110003626415
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles