Effect of Rhatannin on Glutamine Metabolism in Rat Liver
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- 長沢 哲郎
- Department of Biochemistry, Research Institute for WAKAN-YAKU, Toyama Medical and Pharmaceutical University
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- 大浦 彦吉
- Department of Biochemistry, Research Institute for WAKAN-YAKU, Toyama Medical and Pharmaceutical University
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- 野中 源一郎
- Faculty of Pharmaceutical Science, Kyushu University
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- 西岡 五夫
- Faculty of Pharmaceutical Science, Kyushu University
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The present investigation was undertaken to evaluate the effect of rhatannin (condensed tannin purified form Rhei rhizoma) on transamination from glutamine by measuring the individual amino acids formed from α-keto analogues of amino acids with glutamine or glutamane or glutamate in the supernate of rat liver homogenate. Increased glycine formation was observed 2 to 4h after the intraperitoneal administration of rhatannin (12.5mg/kg body weight). Glutamate (derived from glutamine via glutaminase) may not participate in the rhatannin-induced elevation of glyoxylate amination by glutamine. This effect by rhatannin was completely abolished by cycloheximide treatment 30 min prior to rhatannin treatment, while actinomycin D had no effect. With 20 mM glutamine as the amino-donor, the order of effectiveness of 20 mM keto analogues of amino acids was glyoxylate>pyruvate>hydroxypyruvate>phenylpyruvate>α-ketoisocaproate, and little activity was observed with α-ketoisovalerate. Phenylalanine and leucine production rates were enhanced with either glutamine or glutamate in rhatannin-treated rats.The results of the present investigation suggest that the hepatic glutamine transaminase pathway might be enhanced in rhatannin-treated rats. This enhancement might be associated with a protein synthesis process.
収録刊行物
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- Chem. Pharm. Bull.
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Chem. Pharm. Bull. 34 2937-2943, 1986
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詳細情報 詳細情報について
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- CRID
- 1573387452276005760
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- NII論文ID
- 110003626485
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles