Inhibition of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase by Lignan Glucosides of Eucommia Bark

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抄録

Studies were conducted on adenosine 3', 5'-cyclic monophosphate (cyclic AMP) phosphodiesterase inhibition by lignan glucosides from bark of Eucommia ulmoides OLIV. (Eucommiaceae). Various lignan diglucosides. (+)-syringaresinol di-O-β-D-glucopyranoside (1c), (+)-medioresinol di-O-β-D-glucopyranoside (2c), (+)-pinoresinol di-O-β-D-glucopyranoside (3c) and (+)-1-hydroxy-pinoresinol 4', 4"-di-O-β-D-glucopyranoside (4d), showed strong inhibitory activity.The structure-inhibitory activity relationships of the aglycone and its glucosides are discussed. The order of inhibitory effect was diglucoside ≩︀ aglycone > monoglucoside.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 36, 435-439, 1988

    公益社団法人日本薬学会

被引用文献:  5件中 1-5件 を表示

各種コード

  • NII論文ID(NAID)
    110003626710
  • NII書誌ID(NCID)
    AA00602100
  • 本文言語コード
    ENG
  • 資料種別
    雑誌論文
  • ISSN
    00092363
  • データ提供元
    CJP引用  NII-ELS 
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