Isolation and Characterization of Human Urinary Metabolites of Meclomen

• 松木 容彦

  Hatano Research Institute, Food and Drug Safety Center

• 團 純子

  Hatano Research Institute, Food and Drug Safety Center

• 福原 克治

  Hatano Research Institute, Food and Drug Safety Center

• 伊東 富晴

  Hatano Research Institute, Food and Drug Safety Center

• 南原 利夫

  Pharmaceutical Institute, Tohoku University

抄録

The principal metabolites of meclomen (sodium meclofenamate; sodium 2-[(2,6-dichloro-3-methylphenyl)]aminobenzoate monohydrate) were isolated from human urine and characterized by gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (^1H-NMR) spectroscopy together with the Folin-Ciocalteu test. Oxidation occurred at the methyl group at C-3 and/or the aromatic ring in meclomen, yielding the methylol (M-1), dicarboxylic acid (M-2), phenols (M-3 and M-4), 3-hydroxymethylated phenol (M-7), 3-demethylated phenol (M-6) and phenolic dicarboxylic acid (M-8).Among these metabolites, M-1,M-2,M-3 and M-4 are common to fenamate antiinflammatory analgesics. A novel metabolite, M-6,is presumably produced from M-8 through M-7 or M-2 as an intermediate.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 36 (4), 1431-1436, 1988-04-25

  公益社団法人日本薬学会

キーワード

• anti-onflammatory drug
• sodium meclofenamate
• meclomen
• metabolism
• human urinary metabolite
• trace characterization
• GC-MS
• ion cluster

詳細情報

• CRID: 1573105977299359488
• NII論文ID: 110003626933
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1988179693
• 本文言語コード: en
• データソース種別:
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