Studies on Pharmacologically Active Principles from Indonesian Crude Drugs. II. : Hypothermic Principle from Curcuma xanthorrhiza ROXB.

• YAMAZAKI MIKIO

  Faculty of Pharmaceutical Sciences, Chiba University

• MAEBAYASHI YUKIO

  Faculty of Pharmaceutical Sciences, Chiba University

• IWASE NOBUHISA

  Faculty of Pharmaceutical Sciences, Chiba University

• KANEKO YOSHIYUKI

  Japan and Central Research Laboratory, Showa Sangyo Co., Ltd.,

Abstract

Germacrone was identified as a hypothermic principle of Curcuma xanthorrhiza ROXB. When orally administered to mice, germacrone showed the following activities in addition to the hypothermic effect : prolongation of pentobarbital-induced sleeping time, suppression of spontaneous motor activity, suppression of acetic acid-induced writhing, and inhibition of stress-induced ulcer.

Journal

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 36 (6), 2075-2078, 1988-06-25

  The Pharmaceutical Society of Japan

Keywords

• Curcuma xanthorrhiza
• suppressive activity
• germacrone
• hypothermic activity

Details

• CRID: 1572824502321213312
• NII Article ID: 110003627038
• NII Book ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1989012727
• Text Lang: en
• Data Source:
  • CiNii Articles