ANTIOXIDATIVE EFFECT OF SEVERAL PORPHYRINS ON LIPID PEROXIDATION IN RAT LIVER HOMOGENATES

• 今井 公江

  Faculty of Pharmaceutical Sciences, Setsunan University

• 相本 太刀夫

  Faculty of Pharmaceutical Sciences, Setsunan University

• 佐藤 正基

  School of Pharmaceutical Science, University of Shizuoka

• 木村 良平

  School of Pharmaceutical Science, University of Shizuoka

抄録

The effect of several porphyrins on Fe^<2+>-ascorbic acid-stimulated lipid peroxidation was examined in rat liver homogenates. Not only protoporphyrin IX (PP) but also mesoporphyrin IX and hematoporphyrin inhibited the lipid peroxidation. Some porphyrins, in which 6- and 7- carboxyethyl groups were esterified with a methyl group, such as protoporphyrin IX dimethyl ester and mesoporphyrin IX dimethyl ester, had no antioxidative effect. Hemin and zinc protoporphyrin IX, which are metal-chelated porphyrins, inhibited the lipid peroxidation while cobalt protoporphyrin IX and tin protoporphyrin IX showed no antioxidative effect. Thus, some of the porphyrins used in the present study showed an antioxidative effect as did PP, but the others did not show such an effect.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 38 (1), 258-260, 1990-01-25

  公益社団法人日本薬学会

キーワード

• porphyrin
• metalloporphyrin
• lipid peroxidation
• rat liver homogenate

詳細情報

• CRID: 1574231877204687488
• NII論文ID: 110003628109
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1992223669
• 本文言語コード: en
• データソース種別:
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