Palladium-Catalyzed Condensatino of Aryl Halides with Phenylsulfonylsulfonylacetonitrile and Diethyl Cyanomethyl phosphonate

• 坂本 尚夫

  Pharmaceutical Institute, Tohoku University

• 加藤 栄作

  Pharmaceutical Institute, Tohoku University

• 根東 義則

  Pharmaceutical Institute, Tohoku University

• 山中 宏

  Pharmaceutical Institute, Tohoku University

抄録

The palladium(0)-catalyzed condensation of aryl halides with the sodium salts of phenylsulfonylacetonitrile and diethyl cyanomethylphonate in dimethoxyethane gave the corresponding α-phenylsulfonylareneacetonitriles and diethyl arylcyanomethylphosphonates in good yields.The α-phenylsulfonylareneacetonitriles were easily desulfonylated with zinc to give the areneacetonitriles, and the arylcyanomethylphonates were converted to the alkylideneareneacetonitriles by means of the Horner-Emmons reaction.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 38 (6), 1513-1517, 1990-06-25

  公益社団法人日本薬学会

キーワード

• palladium-catalyzed reaction
• aryl halide
• phenylsulfonylacetonitrile
• diethyl cyanomethylphosphonate
• desul-fonylation
• zinc dust
• Horner-Emmons reaction

詳細情報

• CRID: 1570291227531073792
• NII論文ID: 110003628586
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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