Phenolic Compounds from Stem Bark of Acanthopanax senticosus and Their Pharmacological Effect in Chronic Swimming Stressed Rats

• 西部 三省

  Faculty of Pharmaceutical Sciences Higashi Nippon Gakuen University

• 木下 英弘

  Faculty of Pharmaceutical Sciences Higashi Nippon Gakuen University

• 武田 秀勝

  Department of General Education Higashi Nippon Gakuen University

• 岡野 五郎

  Sapporo Medical College

抄録

Ten phenolic compounds, isofraxidin (1), (+)-syringaresinol-di-O-β-D-glucoside (2), syringin (3), chlorogenic acid (4), isofraxidin-7-O-β-D-glucoside (5), 2,6-dimethoxy-p-benzoquinone (6), (+)-pinoresinol-O-β-D-glucoside (7), (+)-syringaresinol-O-β-D-glucoside (8), (+)-pinoresinol-di-O-β-D-glucoside (9), and (+)-medioresinol-di-O-β-D-glucoside (10), were isolated from the stem bark of Acanthopanax senticosus HARMS and identified, respectively.The aquenous extract of the stem bark exhibited a prolonging effect on the exercise time to exhaustion in chronic swimming stressed rats. The effect on the exercise time in the chronic swimming stressed rats was respectively tested for compounds 2 and 4,which are major constituents of the stem bark. As a result, it was indicated that compound 2 is the compound responsible for part of the pharmacological effect which the aqueous extract of the stem bark showed.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 6 1763-1765, 1990

  公益社団法人日本薬学会

キーワード

• Acanthopanax senticosus
• stem bark
• phenolic compound
• (+)-syringaresinol-di-O-β-D-glucoside
• chlorogenic acid
• aqueous extract
• pharmacological effect
• chronic swimming stressed rat
• exhaustion exercise time

詳細情報

• CRID: 1570009752554623488
• NII論文ID: 110003628642
• NII書誌ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1992093645
• 本文言語コード: en
• データソース種別:
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