Lipid A and Related Compounds. XXVI. Syntheses of Biologically Active Penta-O-acetyl-N-glycoloylneuraminyl- and Penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic Acid-(α2→6)-D-glucosamine-4-phosphate Analogs of Lipid A

• 池田 潔

  School of Pharmaceutical Sciences, University of Shizuoka

• 河合 弘毅

  School of Pharmaceutical Sciences, University of Shizuoka

• 阿知波 一雄

  School of Pharmaceutical Sciences, University of Shizuoka

抄録

The syntheses of novel penta-O-acetyl-N-glycoloylneuraminyl- and penta-O-acetyl-3-deoxy-D-glycero-D-galacto-2-nonulopyranosonic acid-(α 2→6)-D-glucosamine-4-phosphate analogues of lipid A containing sialic acid in place of 3-deoxy-D-manno-2-octulosonic acid are described. Preliminary examination of the biological activity revealed that two synthetic disaccharides showed mitogenic activities and weak antitumor activities.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 39 (5), 1305-1309, 1991-05-25

  公益社団法人日本薬学会

キーワード

• N-acetylneuraminic acid
• N-glycoloylneuraminyl-glucosamine-4-phosphate
• KDN-glucosamine-4-phosphate
• lipid A analog
• mitogenic activity

詳細情報

• CRID: 1573105977298625280
• NII論文ID: 110003629325
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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