PERMEABILITY OF GLYCOSIDES THROUGH HUMAN ERYTHROCYTE MEMBRANE
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The permeability of glycosides (arbutin, salicin, glycyrritin, p-nitrophenyl-β-D-glucopyranoside, p-nitrophenyl-β-D-galactopyranoside, p-nitrophenyl-β-D-lactopyranoside, p-nitrophenyl-β-D-maltopyranoside) and their aglycons through human erythrocyte membrane was investigated. The glycosides permeated slowly, compared with their aglycons. Glycoside having disaccharide did not permeate the erythrocyte membrane. This suggested that the introduction of disaccharide to a drug significantly depresses the permeability of glycoside through erythrocyte membrane. The drug entrapped in erythrocytes was not released into the outer medium.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 39 (5), 1346-1348, 1991-05-25
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1571698602415073920
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- NII論文ID
- 110003629340
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles