Factors Affecting Prednisolone Release from Hydrogels Prepared with Water-Soluble Dietary Fibers, Xanthan and Locust Bean Gums

• 渡邉 一則

  Hospital Pharmacy, Tokyo Women's Medical College Daini Hospital Department of Pharmaceutics, Hoshi University

• 谷古宇 秀

  Hospital Pharmacy, Tokyo Women's Medical College Daini Hospital

• 高山 幸三

  Department of Pharmaceutics, Hoshi University

• 町田 良治

  Department of Pharmaceutics, Hoshi University

• 永井 恒司

  Department of Pharmaceutics, Hoshi University

抄録

The release behavior of prednisolone from hydrogels prepared with xanthan and locust bean gums was investigated. Newly developed equipment was employed in order to increase the gum concentration in the hydrogels. The apparent release rate of prednisolone from the hydrogels decreased with increasing gum concentration, suggesting that the diffusion of drug molecules was mainly controlled by the density of the three-dimensional network structure in the matrix. The effect of additives such as glycerin and sucrose on the release behavior of prednisolone was also investigated in detail. Drug release was significantly lowered by the addition of these compounds to these hydrogels. A linear relation was observed between the apparent release rate of prednisolone and the microscopic viscosity of the hydrogels. these results indicated that the drug release could be controlled not only by the density of the network structure but also by the microscopic viscosity of the hydrogels.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 40 459-462, 1992

  公益社団法人日本薬学会

キーワード

• hydrogel
• xanthan gum
• locust bean gum
• release rate
• prednisolone
• three-dimensional network
• swelling
• microscopic viscosity
• glycerin
• sucrose

詳細情報

• CRID: 1570291227531634304
• NII論文ID: 110003629787
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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