Synthesis and Characterization of Furanose and Pyranose Derivatives of 3-Deoxy-D-glycero-D-galacto-2-nonulosonic Acid (KDN)

• 中村 光延

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  School of Pharmaceutical Sciences, Kitasato University

• 古畑 公夫

  School of Pharmaceutical Sciences, Kitasato University

• 小倉 治夫

  School of Pharmaceutical Sciences, Kitasato University

抄録

The products of Fischer's methyl glycosylation of 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) revealed existence of an the anomeric equilibrium between α, β-furanose and α, β-pyranose of KDN. In spite of the anomeric equilibrium, peracetylation of KDN and its derivatives by acetic anhydride with pyridine gave only α- and β-pyranose derivatives. The obtained methyl glycosides and hexa-O-acetyl derivatives were characterized by X-ray, nuclear magnetic resonance and cicular dichroism spectral analyses.

収録刊行物

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 40 879-885, 1992

  公益社団法人日本薬学会

キーワード

• KDN
• anomeric equilibrium
• furanose
• X-ray crystal analysis
• ^1H-NMR

詳細情報

• CRID: 1571698602415828992
• NII論文ID: 110003629889
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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