Inhibitors of Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase from Schisandra chinensis and the Structure Activity Relationship of Lignans

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The structure activity relationship was studied in analogous lignans from Schisandra chinensis and their derivatives. These compounds were tested for cyclic adenosine 3', 5'-monophosphate (cAMP) phosphodiesterase inhibition. An inhibitor, nordihydroguaiaretic acid (13), was isolated from this plant, so we discussed this compound and a derivative, nordihydroguaiaretic acid tetramethyl ether, using molecular mechanics involving three-dimensional modeling and minimization of the structure using the MM2PP program. As a result, it was found that the structure of nordihydroguaiaretic acid tetrametyl ether and papaverine (30) (positive control) shared a similar low energy conformation. This fact suggested that these compounds inhibited cAMP phosphodiesterase by a similar mechanism.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 40, 1191-1195, 1992

    公益社団法人日本薬学会

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各種コード

  • NII論文ID(NAID)
    110003629958
  • NII書誌ID(NCID)
    AA00602100
  • 本文言語コード
    ENG
  • 資料種別
    雑誌論文
  • ISSN
    00092363
  • データ提供元
    CJP引用  NII-ELS 
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