Analgesic Component of Notopterygium incisum TING

• OKUYAMA E.

  Faculty of Pharmaceutical Sciences, Chiba University

• NISHIMURA Satoshi

  Faculty of Pharmaceutical Sciences, Chiba University

• OHMORI Shigeru

  Faculty of Pharmaceutical Sciences, Chiba University

• OZAKI Yukihiro

  National Institute of Hygienic Sciences

• SATAKE Motoyoshi

  National Institute of Hygienic Sciences

• YAMAZAKI Mikio

  Faculty of Pharmaceutical Sciences, Chiba University

Abstract

Notopterol was identified as the analgesic component of Notopterygium incisum TING by using the acetic acid-induced writhing method. Notopterol also indicated an anti-inflammatory activity by its inhibitory effect in the vascular permeability test. The intensive prolongation of pentobarbital-induced hypnosis was possibly caused by its inhibitory effect on the drug metabolism in liver. Pharmacological differences between the analgesic components of N. incisum, Aralia cordata and Angelica pubescens were also discussed.

Journal

• Chem. Pharm. Bull.

  Chem. Pharm. Bull. 41 926-929, 1993

  The Pharmaceutical Society of Japan

Keywords

• notopterol
• analgesics
• Notopterygium incisum
• Tou-kyokatsu
• Qiang-huop
• anti-inflammatory activity

Details

• CRID: 1572543027231178880
• NII Article ID: 110003630522
• NII Book ID: AA00602100
• ISSN: 00092363
• Web Site: https://search.jamas.or.jp/link/ui/1994188506
• Text Lang: en
• Data Source:
  • CiNii Articles