A Widely Applicable Electrode Sensitive to Basic Drugs Based on Poly(vinyl chloride) Membrane Plasticized with Tricresyl Phosphate

• 鈴木 博文

  Pharmaceutical Research Center, Kanebo, Ltd.,

• 中川 寛

  Pharmaceutical Research Center, Kanebo, Ltd.,

• 御舩 正樹

  The Graduate School of Natural Sciences and Technology, Okayama University

• 斎藤 寛

  The Faculty of Pharmaceutical Sciences, Okayama University

抄録

A plastic membrane ion-selective electrode applicable to many basic drugs has been developed. The electrode developed was constructed with tricresyl phosphate and a poly(vinyl chloride) matrix on a polytetrafluoroethylene film. The electrode showed a near-Nernstian response to chlorpromazine, trihexyphenidyl, imipramine, dibucaine, papaverine, propranolol, tetracaine, trazodone, quinidine and cinnarizine. The determination of 50 to 3000 μg/ml of trazodone hydrochloride in a pH 4.0 acetate buffer solution showed an average recovery of 99.4% (mean standard deviation 0.7%) by direct potentiometry. Inorganic cations and pharmaceutical excipients did not interfere with the determination. Trazodone hydrochloride and trihexyphenidyl hydrochloride in tablets were determined, and the results compared favorably with those obtained by conventional methods.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 41 (6), 1123-1126, 1993-06-15

  公益社団法人日本薬学会

キーワード

• ion-selective electrode
• basic drugs
• pharmaceutical analysis
• poly(vinyl chloride) membrane electrode
• tricresyl phosphate
• potentiometry

詳細情報

• CRID: 1571417127324342400
• NII論文ID: 110003630565
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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