Preparation of the solid dispersion of indomethacin with phosphatidylcholine by heating method

この論文をさがす

抄録

The solid dispersion (SD) preparation method of indomethacin (IM, mp 161℃) with phosphatidylcholine (PC) was investigated. The melting point of PC is high, above 200℃, making a melting method inapplicable. However, PC shows a phase transition at about 100℃ when its acyl chains are stearic acid and it is an anhydride. In the case of mole fraction of IM in SD being 0.50,X-ray diffraction patterns suggest that IM is in an amorphous state after heating at 90℃ for 1h, at 110℃ for 10min or at 180℃ for 6min. When the mole fraction of IM is as low as 0.25 or 0.33,IM is also present in an amorphous state after heating at 70℃ for 2h and at 90℃ for 10min. The obtained SD showed endothermic peaks from about 40℃ to 70℃ upon thermal analysis. It is possible to prepare SD above 70℃, but this requires a long heating time; therefore, heating at above the phase transition temperature is most suitable. The dissolution patterns of IM from SD compressed into tablet form were fitted to Higuchi's square root equation and the dissolution rate was found to be 1.5-fold that from a physical mixture of the same composition.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 41 1275-1278, 1993

    公益社団法人日本薬学会

被引用文献 (2)*注記

もっと見る

詳細情報

  • CRID
    1572824502209269632
  • NII論文ID
    110003630601
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

問題の指摘

ページトップへ