Facile Synthesis of 4-Acylamino-2, 6-anhydro-2, 3, 4-trideoxy-D-glycero-D-galacto-non-2-enoic Acids

• 孫 学龍

  School of Pharmaceutical Sciences, Kitasato University

• 甲斐 俊次

  School of Pharmaceutical Sciences, Kitasato University

• 田中 誠

  School of Pharmaceutical Sciences, Kitasato University

• 高柳 弘明

  School of Pharmaceutical Sciences, Kitasato University

• 古畑 公夫

  School of Pharmaceutical Sciences, Kitasato University

抄録

The title compounds were synthesized from 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (5,KDN) by a new method which is similar to the Ritter reaction. The structures on these compounds were elucidated from the MS, elemental analysis, ^1H-NMR and ^<13>C-NMR, data, and the stereochemistry of methyl 4-benzoylamino-5,7,8,9-tetra-O-acetyl-2,6-anhydro-2,3-dideoxy-D-glycero-D-galacto-non-2-enonate (13) was determined by X-ray crystallographic analysis.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 43 (10), 1654-1658, 1995-10-15

  公益社団法人日本薬学会

キーワード

• sialic acid
• 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid
• KDN
• sialidase inhibitor
• Ritter reaction
• acetonitrile

詳細情報

• CRID: 1572261552254968448
• NII論文ID: 110003631324
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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