Tandem Enzymatic Resolution Yielding L-α-Aminoalkanedioic Acid ω-Esters

• NISHINO Norikazu

  Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology

• ARAI Toru

  Department of Applied Chemistry, Faculty of Engineering, Kyushu Institute of Technology

• UENO Yukio

  Central Research Institute, Asahi Glass Co., Ltd.

• OHBA Masataka

  Central Research Institute, Asahi Glass Co., Ltd.

抄録

The tandem action of serine protease (α-chymotrypsin or subtilisin BPN') and Aspergillus genus aminoacylase on racemic N-acetyl-α-aminoalkanedioic acid α, ω-diester produced L-α-aminoalkanedioic acid ω-ester in good yield and high optical purity. L-α-Aminosuberic acid ω-ester thus obtained was conveniently introduced into an oxytocin analog, [Asu^<1,6>]oxytocin, by the solid-phase-synthesis and cyclization-cleavage method with oxime resin.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 44 (1), 212-214, 1996-01-15

  公益社団法人日本薬学会

キーワード

• α-aminoalkanedioic acid
• aminosuberic acid
• tandem enzymatic resolution
• cyclic peptide
• oxytocin analog

詳細情報

• CRID: 1572543027232769024
• NII論文ID: 110003631748
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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