Meisenheimer Rearrangement of Azetopyridoindoles. VIII. Synthesis and Antiviral Activities of 12-Carbaeudistomin Analogs

• KURIHARA Takushi

  Osaka University of harmaceutical Sciences

• SAKAMOTO Yasuhiko

  Osaka University of harmaceutical Sciences

• KIMURA Tetsuya

  Osaka University of harmaceutical Sciences

• OHISHI Hirofumi

  Osaka University of harmaceutical Sciences

• HARUSAWA Shinya

  Osaka University of harmaceutical Sciences

• YONEDA Ryuji

  Osaka University of harmaceutical Sciences

• SUZUTANI Tatsuo

  Asahikawa Midical College, Department of Microbiology

• AZUMA Masanobu

  Asahikawa Midical College, Department of Microbiology

抄録

Eudistomins, isolated from the colonial tunicate Eudistoma olivaceum, have been a synthetic target due to their strong antiviral activity against Herpes simplesx virus (HSV-1) and activities against certain types of tumors in vivo. In order to examine the structure-activity relationship of eudistomins, 12-carbaeudistomin analogs were synthesized and their activities against influenza A and B virus, HSV-1,HSV-2 and human cytomegalovirus were investigated. Among them, racemic 6-methoxy-12-carbaeudistomin showed similar activity to (-)-debromoeudistomin K, synthesized as a control compound.

収録刊行物

• Chemical & pharmaceutical bulletin

  Chemical & pharmaceutical bulletin 44 (5), 900-908, 1996-05-15

  公益社団法人日本薬学会

キーワード

• eudistomin
• 12-carbaeudistomin
• antiviral activity
• Meisenheimer rearrnagement
• structure-activity relationship
• MNDO calculation

詳細情報

• CRID: 1570009752441626112
• NII論文ID: 110003631995
• NII書誌ID: AA00602100
• ISSN: 00092363
• 本文言語コード: en
• データソース種別:
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