Syntheses of Aminoisoquinolines and Related Compounds. V. The Direction of the Mannich Reaction on the Aminotetrahydroisoquinolines to the Aminoprotoberberines

• 石渡 三郎

• 板倉 啓壹

抄録

The Mannich reaction of 1-(3-aminobenzyl) tetrahydroisoquinolines (Va and Vb) with 36% formaldehyde solution in ethanol afforded the corresponding aminoprotoberberines (VIa and IXa, VIb and IXb), formed by the cyclization at the position para and ortho to the amino group and a modified synthesis of 9, 10-disubstituted and 9, 10, 11-trisubstituted protoberberines was accomplished by the reduction or thermal decomposition of the diazonium salts of the aminoprotoberberines.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 18 (5), 896-900, 1970

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679148411392
• NII論文ID: 110003632392
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.18.896
• ISSN: 13475223
• ISSN: 00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/18/5/18_5_896/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1971047031
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可