Studies on the Metabolism of D- and L-Isomers of 3, 4-Dihydroxyphenylalanine (DOPA). I. Autoradiographic Study on the Distribution of <SUP>14</SUP>C-Labeled D-and L-DOPA and Dopamine after Intravenous Administration in Rats
この論文をさがす
抄録
The distribution of D- and L-14C-DOPA and 14C-dopamine were investigated by means of whole-body autoradiographic technique following intravenous injection in rats. Significant differences were found in the distribution pattern of radioactivity between the two isomers, as summarized in the following : i) a rapid and marked uptake of L-DOPA by the brain and the localization in the caudate nucleus, in contrast to a slow and a very low distribution of D-DOPA over the whole brain, ii) an extremely high uptake and a long retention of L-DOPA in the adrenal medulla, iii) a much higher concentration of L-DOPA in the skeletal muscle and liver than D-DOPA, and an appreciably faster initial rate of elimination of D-DOPA into the urine, and iv) an accumulation and a long retention of both isomers in the pancreas, renal medulla and hair follicles, with an appreciably higher concentration in the D-isomer. 14C-Dopamine did not show any radioactivity in the brain, confirming that it cannot pass through the blood-brain barrier. These results were discussed in relation to the possible differences in their metabolism and transport and to the therapeutic effect of L-DOPA against Parkinsonism.
収録刊行物
-
- CHEMICAL & PHARMACEUTICAL BULLETIN
-
CHEMICAL & PHARMACEUTICAL BULLETIN 19 (12), 2490-2500, 1971
公益社団法人 日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282679147748480
-
- NII論文ID
- 110003632630
-
- NII書誌ID
- AA00602100
-
- COI
- 1:CAS:528:DyaE38XhtVOrsLk%3D
-
- ISSN
- 13475223
- 00092363
-
- PubMed
- 5145918
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可