Radioprotective Effect of Pyridoxamine-5-thiophosphate and Related Compounds

• 石井 伸彦

• 黒田 敏男

• 高木 良成

• 赤星 三弥

抄録

Among 6 derivatives of 5-mercaptopyridoxine, pyridoxamine-5-thiophosphate was most powerful in protecting mice from X-radiation. Its efficacy was nearly comparable with that of the typical radioprotector, cysteamine. It was less toxic than any other derivatives tested, the ratio of the median lethal dose to the minimum radioprotective dose was smaller than 1/4. It was effective when administered orally as well as when injected intraperitoneally. Quicker recovery of leucocyte number was observed in the circulating blood of the protected animals than in the controls. The compound protected an enzyme protein (β-glucuronidase) from radiation-inactivation in aqueous solution as powerfully as cysteamine did. However, it was much less effective than cysteamine in protecting HeLa S₃ cells from the loss of reproductive integrity caused by radiation.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 22 (2), 409-412, 1974

  公益社団法人 日本薬学会

キーワード

• Drug Discovery
• General Chemistry
• General Medicine

詳細情報

• CRID: 1390282679153550464
• NII論文ID: 110003633166
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.22.409
• ISSN: 13475223
• ISSN: 00092363
• PubMed: 4845547
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/22/2/22_2_409/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1974071448
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可