Solubility of a new polymorph of phenobarbital obtained by crystallization in the presence of phenytoin.

• 加藤 百合子

• 岡本 由美

• 永沢 佐世子

• 植木 智子

抄録

Physicochemical properties of some polymorphs of phenobarbital were studied. A new polymorph, form III-Ph, with a slightly changed crystal habit was obtained by addition of phenytoin at the time of recrystallization. The transition temperature and the heat of transition between form III-Ph and form III, and between form III and form II were determined to be 46°C and 0.201 kcal/mol, and 77°C and 0.404 kcal/mol, respectively, by solubility measurement. As the dissolution rates of form III-Ph and form III were higher than that of form II, they are expected to show better bioavailability than form II.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 29 (11), 3410-3413, 1981

  公益社団法人 日本薬学会

キーワード

• heat of solution

詳細情報

• CRID: 1390282679141092736
• NII論文ID: 110003633594
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.29.3410
• COI: 1:CAS:528:DyaL38XlslKlsQ%3D%3D
• ISSN: 13475223
• ISSN: 00092363
• ISSN: http://id.crossref.org/issn/00092363
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/29/11/29_11_3410/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1982210761
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可