Effects of geniposide isolated from Gardenia jasminoides on metabolic alterations in high sugar diet-fed rats

  • 木村 善行
    2nd Department of Medical Biochemistry, School of Medicine, Ehime University
  • 奥田 拓道
    2nd Department of Medical Biochemistry, School of Medicine, Ehime University
  • 有地 滋
    The Research Institute of Oriental Medicine, Kinki University

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抄録

The effects of geniposide isolated from Gardeniae Fructus ("San-shi-shi"in Japanese) on metabolic alterations in high sugar diet-fed rats were investigated. It was found that the oral administration of the high sugar diet caused hyperlipemia, liver injury with elevation of glutamic pyruvic transaminase (GPT) in the serum, and the accumulation of lipid peroxide in the liver. Geniposide reduced the serum triglyceride, lipid peroxide, phospholipid, glucose, insulin and GPT in the high sugar diet-fed rats. It was found that the administration of geniposide reduced the sucrase activity in the small intestine and the deposition of lipid peroxide in the liver.

収録刊行物

  • Chem. Pham. Bull.

    Chem. Pham. Bull. 30 4444-4447, 1982

    公益社団法人日本薬学会

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