Studies on peptides. 68. Synthesis of the tritriacontapeptide amide corresponding to the entire amino acid sequence of the desulfated form of porcine cholecystokinin-pancreozymin (CCK-PZ).

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Abstract

The tritriacontapeptide amide, [27-Tyr]-CCK-PZ, was synthesized by successive azide condensation of 4 peptide fragments, (1-5), (6-11), (12-16), and (17-33), followed by exposure to hydrogen fluoride to remove all protecting groups. Though the CCK-PZ activity of synthetic peptide was only 1/250 of the standard from the natural source, it was smoothly labeled with radioactive iodine. Chain length activity relationship of CCK-PZ was also discussed.

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 24(11), 2794-2802, 1976

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    110003634906
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • Data Source
    NII-ELS  J-STAGE 
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