Reaction of sec-amides with metal hydride. II. Reaction of acid chlorides with sodium acetanilidoborohydride.
Access this Article
Search this Article
Sodium acetanilidoborohydride prepared from acetanilide and sodium borohydride in α-picoline reduced acid chlorides to alcohols in dichloromethane. On the other hand, this reducing reagent prepared in pyridine did not reduce acid chlorides but reduced the pyridine ring to give acylpiperidines.
- Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin 24(8), 1939-1943, 1976
The Pharmaceutical Society of Japan