Formation of Spherical Micelles by the Novel Platelet Activating Factor Receptor Antagonist, E5880.

• NOMURA Teruko

• ASAI Yasuyuki

• MURAHASHI Naokazu

• IWAMOTO Kiyoshi

抄録

E5880, a novel platelet activating factor receptor antagonist, was dispersed in water for the preparation of injectable formulation and the physicochemical properties of the micelles were characterized. The critical concentration for formation of micelles was 0.12 mM. Using the area per molecule results, the critical packing parameter was calculated and showed that the structure was composed of spherical micelles and the number of the molecules per micelle was 88. The diameter of a micelle was 8.1 nm. The fluidity and micropolarity around the hydrocarbon region of the micelles were evaluated and compared to the surfactants, stearyltrimethylammmonium chloride and cetyltrimethylammonium chloride.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 48 (7), 947-950, 2000

  公益社団法人 日本薬学会

キーワード

• surface tension
• micelle
• structure
• fluidity
• micropolarity

詳細情報

• CRID: 1390001204161083136
• NII論文ID: 130003948118
• NII論文ID: 110003635580
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.48.947
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 5435497
• PubMed: 10923821
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I5435497
• Web Site: http://www.jstage.jst.go.jp/article/cpb1958/48/7/48_7_947/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可