ROLE OF ADRENERGIC AGONISTS ON GASTRIC SECRETION IN THE RAT

• TANI SATORU

  Faculty of Pharmaceutical Science, Josai University

• MUTO NORIO

  Faculty of Pharmaceutical Science, Josai University

• KAWATA NATSUKO

  Faculty of Pharmaceutical Science, Josai University

抄録

Following previous demonstration that isoproterenol stimulated and norepinephrine inhibited gastric acid secretion induced by secretagogues, role of adrenergic agonists was studied by measuring acidity and peptic activity of the effluent of the perfused rat stomach. Response of gastric secretion to isoproterenol was increased by theophylline treatment but was not affected by metiamide treatment. N^6,O^<2'>-Dibutyryladenosine 3', 5'-cyclic monophosphoric acid sodium salt monohydride (dibutyryl-c-AMP) stimulated gastric secretion in a dose-dependent manner. These results suggest the possibility that the action of isoproterenol in gastric acid secretion is mediated by c-AMP. However, gastric secretion induced by pentagastrin, histamine, or carbamylcholine was not affected by theophylline treatment. N^2,O^<2'>-Dibutyrylguanosine 3', 5'-cyclic monophosphoric acid sodium salt (dibutyryl-c-GMP) did not exert any effect on gastric secretion. Depression of pentagastrin-induced gastric secretion by norepinephrine was reversed by EGTA infusion. Moreover, Ca^<2+> depressed pentagastrininduced gastric secretion. These results suggest that the action of norepinephrine is closely related to the concentration of Ca^<2+>.

収録刊行物

• Journal of pharmacobio-dynamics

  Journal of pharmacobio-dynamics 3 (10), 507-513, 1980-10

  公益社団法人日本薬学会

キーワード

• gastric secretion
• isoproterenol
• norepinephrine
• theophylline
• Ca^<2+>
• EGTA

詳細情報

• CRID: 1571980077277279360
• NII論文ID: 110003635786
• NII書誌ID: AA00704585
• ISSN: 0386846X
• 本文言語コード: en
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