Anticonvulsant action of diazepam in mice pretreated with caffeine

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  • GOTO M
    Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo (Present address) Research and Developmental Laboratories, Hoechst Japan Limited
  • MORISHITA SHIN-ICHI
    Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
  • FUKUDA HIDEOMI
    Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo

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Abstract

Anticonvulsant activities of diazepam in mice given pentylenetetrazol (PTZ), as well as effects of diazepam against potentiating activities of caffeine on these convulsions, were studied. Electroencephalographic (EEG) and electromyographic (EMG) recordings and behavioral observations were employed. First spike, clonic and tonic convulsions induced by PTZ were readily recognized from the EEF recording coupled with EMG recording. Pretreatment of mice with diazepam suppressed the incidence of clonic and tonic convulsions, but did not affect the development of first spike. These anticonvulsive effects of diazepam were also observed when PTZ-induced convulsions were potentiated with caffeine, except for clonic convulsion which was not suppressed with diazepam. The mechanisms of the antagonistic effects between diazepam and caffeine are discussed.

Journal

  • J. Pharm. Dyn.

    J. Pharm. Dyn. 6 654-659, 1983

    The Pharmaceutical Society of Japan

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