Metabolic disposition of ethyl eicosapentaenoate and its metabolites in rats and dogs

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著者

    • ISHIGURO J
    • Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
    • TADA Toshito
    • Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
    • OGIHARA Takuo
    • Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.
    • OHZAWA Nobuo
    • Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.

抄録

When orally administered to rats, ^<14>C-labelled ethyl eicosapentaenoate (^<14>C-EPA-E) was hydrolyzed and, in the lymph, incorporated mainly into triglycerides (TG) in chylomicrons. In plasma and other tissues, eicosapentaenoic acid (EPA) and its metabolites, such as docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), were detected in TG and phospholipid fractions. In plasma, EPA and its metabolites were found to be integrated into lipoproteins. Tissue distribution of these metabolites showed characteristic patterns from one tissue to another, as did their compositional distribution in lipids. EPA, DPA and DHA were found to be metabolized via β-oxidation in in vitro experiments with mitochondrial fraction.

収録刊行物

  • J Pharmacobiodyn.

    J Pharmacobiodyn. 11, 251-261, 1988

    公益社団法人日本薬学会

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各種コード

  • NII論文ID(NAID)
    110003636862
  • NII書誌ID(NCID)
    AA00704585
  • 本文言語コード
    ENG
  • 資料種別
    雑誌論文
  • ISSN
    0386846X
  • データ提供元
    CJP引用  NII-ELS 
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