Molecular weight dependence of permselectivity to rat small intestinal blood-lymph barrier for exogenous macromolecules absorbed from lumen

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The permselectivity to the small intestinal blood-lymph barrier for the exogenous macromolecules absorbed from the lumen was investigated using in situ rat closed loop experiment. We chose the fluorescein isothiocyanate-labelled dextran (FD) as macromolecule and lipid-surfactant mixed micelles as an absorption promoter. The mean molecular weights of FDs used were 1050O, 17500,3900O and 64200 (abbreviated : FD10,20,40 and 70). The lymph/plasma ratios of FDs concentrations during 5 h post administration were 0.2 - 1.2 (FD10), 0.4-1.3 (FD20), 1.3-7.2 (FD40) and 2.6-11.9 (FD70), respecrively. The FD40 and FD70 levels in the lymph were significantly higher than those in the plasma. The cumulative amounts (% of the absorbed quaratity) of FDs in the lymph from the lumen of the small intestine for 5 h after administration were 0.46% (FD10), 0.51% (FD20), 1.17% (FD40) and 1.89% (FD70), respectively. These findings suggest that the threshold molecular weight of FD for the transfer into the lymphatics with higher level compared to the blood concentration from the lumen across the small intestinal blood-lymph barrier exists between 17500 and 39000.

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  • J Pharm Dyn

    J Pharm Dyn 7 1-6, 1984

    公益社団法人日本薬学会

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