INTESTINAL ABSORPTION OF SALICYLAMIDE AND EFFECT OF ATROPINE ON IT
-
- SHIBASAKI SHIGEKI
- School of Pharmaceutical Science, Toho University
-
- YOKOYAMA MASAYUKI
- School of Pharmaceutical Science, Toho University
-
- BANDO AYA
- School of Pharmaceutical Science, Toho University
-
- NISHIGAKI RYUICHIRO
- School of Pharmaceutical Science, Toho University
-
- UMEMURA KOSHIRO
- School of Pharmaceutical Science, Toho University
この論文をさがす
抄録
The effect of atropine (ATR), a parasynpatholytic agent, on the intestinal absorption of salicylamide (SAM) was studied using the absorption kinetic model proposed by Winne et al. The disappearance of SAM from perfusate and the appearance in intestinal blood were determined using perfused intestinal loop of the rat in vivo. The results showed that the absorption of SAM was simulated by the four compartment model consisting of luminal, interstitial, blood and serosal compartments. The model was assumed to have three rate determining factors, namely mucosal membrane permeability, clearance by blood flow and serosal membrane permeability. ATR decreased the absorption of SAM by decreasing the clearance factor relating to intestinal blood flow and increased the fraction of the transported amount of SAM from interstitia1 space to serosal compartment.
収録刊行物
-
- Journal of pharmacobio-dynamics
-
Journal of pharmacobio-dynamics 8 (4), 296-304, 1985-04
公益社団法人日本薬学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1573950402115504000
-
- NII論文ID
- 110003637952
-
- NII書誌ID
- AA00704585
-
- ISSN
- 0386846X
-
- 本文言語コード
- en
-
- データソース種別
-
- CiNii Articles