Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV. Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion.

• Baba Masaki

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Jin Yongri

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Mizuno Atsuo

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Suzuki Hisaya

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Okada Yoshihito

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

• Takasuka Nobuo

  Experimental Pathology and Chemotherapy Division, National Cancer Center Reseach Institute

• Tokuda Harukuni

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Nishino Hoyoku

  Department of Biochemistry, Kyoto Prefectural University of Medicine

• Okuyama Toru

  Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University

Bibliographic Information

Other Title

• Studies on Cancer Chemoprevention by Traditional Folk Medicines 14. Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion

Abstract

7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum Michx. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein–Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 25 (2), 244-246, 2002

  The Pharmaceutical Society of Japan

Keywords

• <i>Heracleum lanatum</i>
• anti-tumor promoting activity
• ornithine decarboxylase (ODC)
• 7-isopentenyloxycoumarin

Details

• CRID: 1390001204627556224
• NII Article ID: 110003638647
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.25.244
• COI: 1:CAS:528:DC%2BD38XkslWlurs%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 6057717
• PubMed: 11853175
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6057717
• Web Site: http://www.jstage.jst.go.jp/article/bpb/25/2/25_2_244/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2002175303
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed