Toxic Interactions between Disopyramide and Propranolol in Chick Embryos.

• YOSHIYAMA Yuji

• SUGIYAMA Takashi

• MIYAZAKI Hiroyuki

• KANKE Motoko

• SHIMADA Hideyo

書誌事項

タイトル別名

• Toxic Interactions between Disopyramide

抄録

The toxic interaction between disopyramide and propranolol were studied in chick embryos. Fertilized eggs of White Leghorns were incubated and investigated. Disopyramide with and without propranolol was injected into the air sac of a fertilized egg on the 16th day of incubation. Electrocardiograms (ECGs) were recorded 0 to 60 min after the injection. After each drug injection alone, the heart rate was not different compared with control. However, the heart rate was significantly decreased by combination with disopyramide and propranolol. In addition, arrhythmia was produced by disopyramide 1.0 mg/egg alone and in combination with propranolol. These findings indicate that the interaction between disopyramide and propranolol has a marked influence on the heart rate in chick embryos.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (12), 1310-1312, 1997

  公益社団法人 日本薬学会

キーワード

• toxic interaction
• disopyramide
• propranolol
• chick embryo
• electrocardiogram

詳細情報

• CRID: 1390001204622938880
• NII論文ID: 110003639004
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.1310
• COI: 1:CAS:528:DyaK1cXjt1Om
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4371373
• PubMed: 9448111
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4371373
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/12/20_12_1310/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1998130100
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可