Effect of a New Hypoglycemic Agent,A-4166〔(-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine〕,on Postprandial Blood Glucose Excursion:Comparison with Voglibose and Glibenclamide

• IKENOUE Takao

• OKAZAKI Kyoko

• FUJITANI Shoji

• TSUCHIYA Yoshiharu

• AKIYOSHI Megumi

• MAKI Toshio

• KONDO Nobuo

書誌事項

タイトル別名

• Effect of a New Hypoglycemic Agent, A-4166 ((-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine), on Postprandial Blood Glucose Excursion: Comparison with Voglibose and Glibenclamide.
• Effect of a New Hypoglycemic Agent A-41

抄録

(-)-N-(trans-4-Isopropylcyclohexanecarbonyl)-D-phenylalanine (A-4166) is a new nonsulfonylurea hypoglycemic agent that lowers blood glucose by stimulating insulin release. In the present study, we examined the effects of A-4166, voglibose (an α-glucosidase inhibitor), and glibenclamide (a sulfonylurea) on the postprandial glycemic increase in rats with or without diabetes millitus. Oral administration of A-4166 (25-100 mg/kg) dose-dependently decreased blood glucose with a rapid onset and short duration in normal rats. On the other hand, glibenclamide (1-4 mg/kg) showed a slower onset of its hypoglycemic action, and voglibose (0.2 mg/kg) had no effect. In the case of postprandial glucose excursion, the carbohydrate-induced increase in blood glucose was reduced by oral administration of either A-4166 or voglibose without causing sustained hypoglycemia in both normal and neonatal streptozotocin-induced diabetic rats. However, the efficacy of voglibose varied with the type of carbohydrate load. Glibenclamide produced a prolonged decrease in blood glucose without any appreciable effect on the initial glucose excursion. After sucrose loading, plasma insulin levels during the initial 1 h were significantly higher in A-4166-treated rats than in control rats, while voglibose completely inhibited the insulin response to sucrose. In glibenclamide-treated rats, an augmented insulin response was not seen. In conclusion, unlike other hypoglycemic agents, A-4166 suppresses postprandial glucose excursions by stimulating the early phase of insulin secretion.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 20 (4), 354-359, 1997

  公益社団法人 日本薬学会

キーワード

• A-4166
• voglibose
• glibenclamide
• postprandial blood glucose excursion
• insulin secretion

詳細情報

• CRID: 1390001204621610496
• NII論文ID: 110003639056
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.20.354
• COI: 1:CAS:528:DyaK2sXislahtbs%3D
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4188169
• PubMed: 9145209
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4188169
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/20/4/20_4_354/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1997173048
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可