The Effect of Keishi-bushi-to on Collagen-Induced Arthritis

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Author(s)

Abstract

To evaluate the usefulness of a traditional Chinese medicine (Kampo prescription), Keishi-bushi-to (KBT), which is composed of five medicinal plants derived from Kampo prescriptions used to treat rheumatoid arthritis, we investigated the effect of KBT on the development of arthritis induced by type II collagen (CII). Oral administration of KBT at a dose of 500 mg/kg from 7d before intradermal injection of CII significantly reduced the severity from 7d after the onset of arthritis. The reduction in body weight resulting from the development of arthritis was not seen in rats treated with KBT.Plasma IgG and IgM anti-CII antibody levels were lower in KBT-treated rats than control rats. In addition, the clearane of IgG anti-CII-antibody from circulating blood after intravenous injection was faster in KBT-treated rats than control rats. These results indicate that KBT is effective in suppressing collagen-induced arthritis and its effect is at least partly due to the suppression of humoral and cellular immunity.

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 20(4), 376-380, 1997-04-15

    The Pharmaceutical Society of Japan

References:  29

Cited by:  5

Codes

  • NII Article ID (NAID)
    110003639060
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    09186158
  • NDL Article ID
    4188173
  • NDL Source Classification
    ZS51(科学技術--薬学)
  • NDL Call No.
    Z53-V41
  • Data Source
    CJP  CJPref  NDL  NII-ELS  J-STAGE 
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