Mechanisms by Which Hange-shashin-to Reduces Prostaglandin E2 Levels.

• KASE Yoshiko

• SAITOH Kazuko

• ISHIGE Atsushi

• KOMATSU Yasuhiro

書誌事項

タイトル別名

• Mechanisms by Which Hange-shashin-to Re

抄録

To determine the mechanisms by which Hange-shashin-to (TJ-14) reduces prostaglandin E2 (PGE2) levels, the effects on blood corticosterone levels were examined in vivo and the effects on cyclooxygenase (COX) activity in virto assessed. TJ-14, orally administered to rats at dose levels between 125 and 1000 mg/kg, caused a dose-dependent increase in blood corticosterone levels. We also showed that Glycyrrhizae Radix and Ginseng Radix, constituents of TJ-14, are involved in the increase in blood corticosterone. The activity of COX-1 was not inhibited by TJ-14 even at a dose of 1000 μg/ml, while COX-2 was inhibited at dose levels between 10 and 1000 μg/ml. The constituents Scutellariae Radix, Glycyrrhizae Radix and Coptidis Rhizoma were believed to be involved in COX-2 inhibition.These results suggest that the effect of TJ-14 in decreasing PGE2 is partially mediated by corticosterone and inhibition of COX-2.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 21 (12), 1277-1281, 1998

  公益社団法人 日本薬学会

キーワード

• Hange-shashin-to
• corticosterone
• cyclooxygenase-1 (COX-1)
• cyclooxygenase-2 (COX-2)

詳細情報

• CRID: 1390001204625665024
• NII論文ID: 110003639283
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.21.1277
• COI: 1:CAS:528:DyaK1MXivFGk
• ISSN: 13475215
• ISSN: 09186158
• ISSN: http://id.crossref.org/issn/09186158
• NDL書誌ID: 4626325
• PubMed: 9881638
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I4626325
• Web Site: http://www.jstage.jst.go.jp/article/bpb1993/21/12/21_12_1277/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999110690
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
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